I know not many people who have full desktop environments use keyboard short. But for tho who do how do you have your keyboard shortcuts set up? here mine
Win+Shift+s to open the GUI of the screenshots tool (I sometimes need the timer). This one is for consistency with Windows 10, that I still use at work ¯\_(ಠ_ಠ)_/¯
I usually only configure 2 custom shortcuts. I remap CTRL-ALT-DEL to shutdown -h now and I make CTRL-ALT-R reboot with shutdown -r now. I have used CTRL-ALT-M to launch Thunderbird, but I don't do this consistently.