Fsync and Esync
Proton has had esync since its first release, which aims to reduce the performance overhead of Wine, especially in CPU bound scenarios. Fsync is a more recent alternative with even better performance improvements. However, you do need a kernel that supports it, and if your kernel does not, it should be considered an 'advanced' step compared to others in this guide. Installation instructions for the necessary kernels are
here.
Within Steam, Esync is enabled by default, and Fsync is enabled by default if your system supports it. In Lutris, for Esync you need to enable in in the runner options, and for Fsync you can add WINEFSYNC=1 as an environmental variable.